Healing Atopic Dermatitis from the Inside Out

Struggling with Eczema?
Eczema at any age can feel frustrating, persistent, and confusing - especially when conventional treatments like corticosteroid creams, antihistamines, or barrier moisturizers only provide short-term relief. While eczema is often thought of as a childhood condition, adult-onset eczema is on the rise and it tends to be more chronic, inflammatory, and emotionally taxing.
As a naturopathic doctor, I view eczema not just as a surface-level skin issue, but as a signal from the body that deeper imbalances may be at play, particularly within the gut, immune system, nutrient status, and stress response. This is why true, long-term relief requires more than suppressing symptoms. It calls for a root-cause, individualized approach.
In this blog post, I’ll walk you through how I support adults with eczema using evidence-informed naturopathic care. We’ll explore how gut health, immune modulation, targeted nutrients like L-histidine, omega-3s, and specific probiotics, as well as topical strategies and stress management techniques, work together to calm inflammation, restore the skin barrier, and prevent future flares.
If you’ve been searching for a more comprehensive, natural, and research-backed path to managing your eczema then you are in the right place. Let’s get to the root of it.

The Initial Investigation
Managing skin conditions is so much more than just what meets the eye, it goes deep beneath the surface to uncovering how your body as a unit is functioning. When it comes to chronic or adult-onset eczema, symptom management isn’t enough. To truly address eczema from a naturopathic and functional medicine perspective, we need to understand what’s driving your inflammation - starting with the inside and moving out.
This starts with a comprehensive clinical investigation, which goes far beyond simply diagnosing “eczema.” Instead, we explore your unique triggers, assess the health of your gut and immune system, examine your daily habits, and review your internal and external environment — all through the lens of root-cause medicine.
Here’s what that process typically looks like in practice:
- Your full symptom picture and health history
- Gut health and digestion
- Your current skincare routine and product use
- Environmental and lifestyle exposures
- Potential food and immune triggers
We may also use targeted lab testing to guide our plan. This can include routine blood work, Food Sensitivity Testing (FST), and the GI-MAP, a functional stool test that gives a detailed look at your microbiome, inflammation markers, and digestive function.
These insights help us understand the why behind your flares — so we can create a care roadmap that’s specific, effective, and rooted in your unique biology.
Start with the Gut
There is a growing body of evidence supporting the connection between the gut microbiome and skin health — often referred to as the gut–skin axis. Dysbiosis (imbalanced gut flora), increased intestinal permeability ("leaky gut"), and chronic low-grade inflammation can all contribute to eczema in adults. Treating the gut symptoms lead to better outcomes in treating your skin conditions.
- Bloating, gas, constipation, or irregular bowel movements
- A history of frequent antibiotic use, food poisoning, or gut infections
- Food sensitivities or intolerances
- Skin flares that worsen with certain foods

The Immune System & Inflammation
Eczema is an immune-mediated condition involving Th2-dominant immune activity, histamine release, and sometimes elevated eosinophils or IgE. In naturopathic care, we aim to calm this overactive immune response by supporting regulatory pathways (like T-reg cells), modulating histamine, and decreasing systemic inflammation. There’s also increasing research suggesting a link between micronutrient deficiencies and eczema, playing a direct role in immune regulation and maintaining the integrity of the skin barrier.
Research-backed nutraceuticals that may support these inflammatory pathways include:
- L-histidine - an essential amino acid that plays a critical role in forming filaggrin, a protein that supports the skin barrier. People with eczema often have mutations or deficiencies in filaggrin production, which compromises the skin’s ability to retain moisture and defend against irritants. Supplementing with L-histidine has been shown to improve skin hydration and reduce eczema severity. A double-blind clinical trial found that oral L-histidine supplementation reduced eczema severity scores in adults with atopic dermatitis within four weeks, without side effects.
- Probiotics - specifically Lactobacillus rhamnosus GG, has been shown to reduce eczema severity by influencing immune tolerance and supporting gut and skin barrier function.
- Omega-3 fatty acids - Omega-3's possess anti-inflammatory properties and skin barrier benefits. Studies show omega-3 supplementation can improve skin hydration, reduce itching, and decrease the need for corticosteroid creams in eczema patients.
- Quercetin and vitamin C - both natural antihistamines that reduce histamine burden and oxidative stress.
- Zinc, vitamin D - supports skin healing and immune response harmony.
Nutrition is Foundational
Nutrition is one of the most powerful tools we can use to support both the skin and immune system. A diet that reduces inflammation, supports gut flora, and nourishes the skin barrier is at the heart of eczema management.
Common nutrition strategies:
- Anti-inflammatory whole food diet: rich in vegetables, healthy fats (olive oil, fatty fish), clean protein, and low in processed foods and added sugars
- Identification and removal of trigger foods: common foods can include cows dairy, gluten, eggs, or other histamine-rich foods
- Rebuilding the microbiome: through prebiotic foods, fermented foods (like sauerkraut, kefir), and targeted supplementation as indicated on an individual basis
The Stress–Skin Connection
Stress is often underestimated in eczema care. However, chronic psychological stress directly impairs skin barrier function, increases inflammation, and can worsen itch and flare cycles. Integrating stress modulation into your eczema plan is non-negotiable.
This may include:
- Nervine botanicals like L-theanine and ashwagandha when indicated on an individual basis
- Guided breathwork, meditation, or nervous system regulation techniques
- Acupuncture and mindfulness-based stress reduction (MBSR), which have shown clinical promise in inflammatory skin conditions
Topical Therapies with Purpose
While internal healing is critical, targeted topical support can bring comfort and reduce the severity of flares and itching/irritation. I recommend evidence-informed botanicals and barrier-supporting topicals like:
- Calendula or chamomile-based creams for inflammation and itch
- Vitamin B12 applied topically - often referred to as 'pink magic'
- Colloidal oatmeal to support the skin microbiome and soothe irritation
- Ceramide-rich moisturizers to restore the lipid barrier
- Avoidance of harsh soaps or overly alkaline cleansers which disrupt the skin’s protective acid mantle

Individualized Care is Key
There is no one-size-fits-all solution to eczema. What works for one person may not work for another — which is why root-cause investigation and personalized care is at the core of naturopathic medicine. Your eczema journey may require adjustments over time, especially as seasons change, hormone levels shift, or stress levels vary.
If you’re tired of chasing temporary fixes and want to heal your skin from within, I invite you to book a 1:1 consultation. Together, we’ll uncover the underlying drivers of your eczema and create a customized plan that supports long-term skin health, gut balance, and resilience.
Are you ready to Take a Root-Cause Approach to Your Eczema?
References
- Kim, J., & Kim, B. E. (2020). The microbiome in atopic dermatitis. Clinical Immunology, 219, 108564. https://doi.org/10.1016/j.clim.2020.108564
- Navarro-López, V., Ramírez-Boscá, A., Ramón-Vidal, D., et al. (2018). Effect of oral administration of a mixture of probiotic strains on SCORAD index and use of topical steroids in young patients with moderate atopic dermatitis: a randomized clinical trial. JAMA Dermatology, 154(3), 324–327. https://doi.org/10.1001/jamadermatol.2017.5142
- Totte, J. E. E., van Doorn, M. B., & Pasmans, S. G. M. A. (2013). Successful treatment of chronic severe atopic dermatitis with the addition of topical vitamin B12: a randomized controlled trial. British Journal of Dermatology, 169(4), 922–924. https://doi.org/10.1111/bjd.12443
- Yaghmaie, P., Koudelka, C. W., & Simpson, E. L. (2013). Mental health comorbidity in patients with atopic dermatitis. Journal of Allergy and Clinical Immunology, 131(2), 428–433. https://doi.org/10.1016/j.jaci.2012.10.041
- Wong, S. M. Y., Dolan, R. D., & Cross, H. H. (2022). The effects of essential fatty acids on atopic dermatitis: a meta-analysis. Nutrients, 14(4), 790. https://doi.org/10.3390/nu14040790
- Jang, S. E., et al. (2018). Effects of Lactobacillus rhamnosus on atopic dermatitis in children: A randomized, double-blind, placebo-controlled trial. Journal of Clinical Medicine, 7(9), 261. https://doi.org/10.3390/jcm7090261
- Tan, S. P., Brown, S. B., Griffiths, C. E. M., Weller, R. B., & Gibbs, N. K. (2017). Feeding filaggrin: effects of l‑histidine supplementation in atopic dermatitis. Clinical, Cosmetic and Investigational Dermatology, 10, 403–411. https://doi.org/10.2147/CCID.S146760
- Gibbs, N. K., et al. (2020). L‑Histidine supplementation in adults and young children with atopic dermatitis. American Society for Nutrition. https://doi.org/10.1093/ajcn/nqaa055
- Rothkopf, M. (2020). Results of Histidine Supplementation in a Case of Severe Nummular Eczema. Current Developments in Nutrition, 4(Suppl 2):1141. https://doi.org/10.1093/cdn/nzaa055_026
- Smith, A. et al. (2015). A pilot study investigating the efficacy of botanical anti-inflammatory agents in an OTC eczema therapy. Journal of Dermatology Treatment, 25 subjects, 2 week application. Wiley Periodicals, Inc. (2015).
